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Title 

Involvement of meiotic maturation of Oocytes in promoting granulosa cell proliferation

Authors 

Kyu Tae ChangDong Un HanTae Yoon KimDong Soo SonMun Il KangByung Hwa HyunByoung Gil Mheen

Publisher 

Society for Reproduction and Development

Issue Date 

2000

Citation 

Journal of Reproduction Development, vol. 46, no. 3, pp. 139-145

Keywords 

oocytegranulosa cellFSHTGF-βTNF-α

Abstract 

The effect of porcine oocytes on the proliferation of rat granulosa cells was studied in a heterologous culture system. Morphologically high quality oocytes showed a more potent stimulatory effect on DNA synthesis in granulosa cells than low quality oocytes. This stimulatory effect of porcine oocytes was enhanced by FSH and cAMP, but was unaffected by both transforming growth factor-β and tumor necrosis factor-oc. Maturation of porcine oocytes in vitro attenuated the stimulatory effect of FSH and cAMP on granulosa cell DNA synthesis. In addition, rat oocytes also exhibited a similar facilitatory effect on DNA synthesis in rat granulosa cells. These results suggest that a soluble factor(s) secreted from oocytes, the secretion of which is dependent on their meiotic progression, can stimulate proliferation of rat granulosa cells in a heterologous culture system. The molecular nature of the factor(s) remains to be elucidated.

ISSN 

0916-8818

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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