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Title 

Analytical techniques for vancomycin - A review

Authors 

Avinash P SatturJe Hyuk LeeKi Bang SongT PandaChul Ho KimSang Ki RheeB Gokul

Publisher 

Springer Verlag (Germany)

Issue Date 

2000

Citation 

Biotechnology and Bioprocess Engineering, vol. 5, no. 3, pp. 153-158

Keywords 

vancomycindalbaheptapeptidesamylocolaptosis orientalisglycopeptideanalytical methods

Abstract 

Vancomycin belongs to the vancomycin-ristocetin family of glycopeptides, and is a subclass of linear sugar containing peptides composed of seven amino acids. Its stereochemical configuration forms the basis of a particular mode of action, though its complexation with the D-alanyl-D-alanine terminus of peptidoglycon monomer. The glycosylated hexapeptide chain consists of chloro-β-hydroxytyrosines, p-hydroxyphenylglycines, N-methylleucine and aspartic acid forms a rigid molecular frame work and gives the difficulty in the analysis. Vancomycin in the serum samples is usually estimated by liquid chromatography and the bacterial sensitivity was genereally tested by the microbiological assay. The present review deals with the qualitative, quantitative, microbiological and immunological assays and the comparison of the quantitative methods. Clinical implications of vancomycin have also been cited in the review.

ISSN 

1226-8372

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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