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Title 

Effects of naringin and lovastatin on plasma and hepatic lipids in high-fat and high-cholesterol fed rats

Authors 

Song Hae BokYong Won ShinKi Hwan BaeTae Sook JeongYong Kook KwonYong Bok ParkMyung Sook Choi

Publisher 

Elsevier

Issue Date 

2000

Citation 

Nutrition Research, vol. 20, no. 7, pp. 1007-1015

Keywords 

cholesteroltriglyceridenaringinlovastatinHMG-CoA reductaseACAT

Abstract 

The effects of naringin on lipid metabolism were examined in rats that were fed a high, fat (15 g lard/100 g) and high-cholesterol (1 g/100 g) diet. Low- or high-doses (0.02 g or 0.05 g/100 g) of either naringin or lovastatin were supplemented in an experimental diet for 35 d. The concentrations of plasma total cholesterol were significantly lower in the naringin- and lovastatin-supplemented groups than in the control group fed a basal diet. In addition, both doses of lovastatin and a high-dose naringin significantly lowered plasma triglyceride concentrations compared to the control group. All naringin and lovastatin supplements, except for the high-dose lovastatin, significantly lowered the hepatic cholesterol concentration compared to the control group. The concentrations of hepatic triglyceride in the naringin- supplemented groups (0.34±0.06 mmol/g and 0.30±0.06 mmol/g) and control (0.33±0.06 mmol/g) were significantly lower than in the lovastatin- supplemented groups (0.40±0.03 mmol/g and 0.42±0.05 mmol/g). High and low doses of naringin significantly lowered the activities of 3-hydroxy-3-methyl- glutaryl-coenzyme A (HMG-CoA) reductase by 54% and 39%, respectively, compared to the control group, while lovastatin did not demonstrate any inhibitory activity on this enzyme. The activities of acyl coenzyme A:cholesterol O-acyltransferase (ACAT) were significantly lower in all experimental groups than in the control. Accordingly, lipid-lowering action of naringin seems to be different from that of lovastatin in a high-fat and high-cholesterol fed rats.

ISSN 

0271-5317

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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