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Title 

Brevibacterium ketoglutamicum을 이용한 L-ornithine 생산 연구 part 1 : L-ornithine 생산 고역가 안정화 균주 선발

Authors 

Wuk Sang RyuHyung Wook JangHong Weon LeeJoon ki JungSoon Jae ChangYeon Woo RyuYoung Hoon Park

Publisher 

Korean Journal of Applied Microbiology and Biotechnology

Issue Date 

1999

Citation 

Korean Journal of Applied Microbiology & Biotechnology, vol. 27, no. 4, pp. 292-297

Keywords 

L-ornithinerevertant formationcell stability

Abstract 

Over production of L-ornithine by mutant strains isolated from Brevibacterium ketoglutamicum BK1046 was investigated. The strain was a L- citrulline auxotroph and exhibited culture instability during fermentation. Through a sequential screening effort, a highly stable strain with less revertant formation was finally selected and designated B. ketoglutamicum BK52 (KCTC 0141BP). It produced L-ornithine at a high concentration (above 9 g/L) independent of subculture or cultivation time, and also had a very low tendency of revertant formation. In a long-term storage, this strain maintained its cell stability and productivity of L-ornithine to a reasonable range.

ISSN 

0257-2389

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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