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Title 

Immunomodulating activity of a polysaccharide isolated from mori cortex radicis

Authors 

Hwan Mook KimSang Bae HanKi Hoon LeeChang Woo LeeChul Young KimEun Ju LeeHoon Huh

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2000

Citation 

Archives of Pharmacal Research, vol. 23, no. 3, pp. 240-242

Keywords 

immunomodulationMorus albapolysaccharideproliferationdifferentiationantibody production

Abstract 

The immunomodulating activity of a polysaccharide isolated from Morus alba (PMA) root bark was examined in murine splenic lymphocytes. PMA enhanced proliferation of splenic lymphocytes in a synergistic manner in the presence of mitogens. However, PMA suppressed primary IgM antibody production from B cells, which was activated with lipopolysaccharide, a polyclonal activator, or immunized with a T-cell dependent antigen sheep red blood cells. Our observations showed that the immunomodulating activity of PMA increased lymphocyte proliferation and that PMA decreased antibody production from B cells, which was distinct from those of other plant-originated polysaccharides.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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