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Title 

Flavonol glycoside gallate and ferulate esters from Persicaria lapathifolia as inhibitors of superoxide production in human monocytes stimulated by unopsonized zymosan

Authors 

Young Soo KimDae Sig JangSi Hyung ParkJi Eun YunBo Kyung MinKyung Rak MinHyeong Kyu Lee

Publisher 

Georg Thieme Verlag

Issue Date 

2000

Citation 

Planta Medica, vol. 66, no. 1, pp. 72-74

Keywords 

superoxidezymosanhumanhuman cellmonocyteestershumansmonocytessuperoxides

Abstract 

Aerial parts of Persicaria lapathifolia S.F. Gray (Polygonaceae) exhibited an inhibitory effect on superoxide production in unopsonized zymosan-stimulated human monocytes. Two known compounds, quercetin 3-O-β- (2''-galloyl)-glucopyranoside and quercetin 3-O-β-(2''-galloyl)- rhamnopyranoside, and a new compound, quercetin 3-O-β-(6''-feruloyl)- galactopyranoside, were isolated as the inhibitors of superoxide production by activity-guided fractionation. IC50 values were shown at the concentrations of 2.1 μM by quercetin 3-O-β-(2''-galloyl)-glucopyranoside, 1.9 μM by quercetin 3-O-β-(2''-galloyl)-rhamnoypranoside, and 3.5 μM by quercetin 3-O-β-(6''-feruloyl)-galactopyranoside whose inhibitory potencies were similar to oxyphenylbutazone (IC50 = 1.9 μM) as a positive control.

ISSN 

0032-0943

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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