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Title 

Effects of triterpenoids from Pueraria lobata on immunohemolysis: β-d-glucuronic acid plays an active role in anticomplementary activity in vitro

Authors 

Sei Ryang OhJunei KinjoYuichi ShiiTuyoshi IkedaToshihiro NoharaKyung Seop AhnJung Hee KimHyeong Kyu Lee

Publisher 

Georg Thieme Verlag

Issue Date 

2000

Citation 

Planta Medica, vol. 66, no. 6, pp. 506-510

Keywords 

pueraria Iobataleguminosaesophoradiol saponinssoyasapogenol B saponinsanticomplementary activityglucuronic acid of saponin

Abstract 

The anticomplementary properties of kaikasaponin III (4) and soyasaponin I (8) from Pueraria Iobata and their hydrolytic analogs were investigated in vitro. Diglycosidic saponins [kaikasaponin I (3), soyasaponin III (7)] showed most potent anticomplementary activities, followed by monoglycosidic saponins [soyasapogenol B monoglucuronide (6), sophoradiol monoglucuronide (2)] and triglycosidic saponins [soyasaponin I (8), kaikasaponin III (4)], whereas sophoradiol (1) and soyasapogenol B (5) showed enhancement of hemolysis under the presence of serum on the classical pathway of complement system. But all of them showed very weak or no anticomplementary activities on the alternative pathway of complement system. The anticomplementary activity of the saponins was influenced by the nature of glucuronic acid, where the free acid forms (-COOH) showed much more potent activity than the sodium salt forms (-COO-Na+) or methyl ester forms (-COOCH3), and the reduced forms (-CH2OH) decreased the activity significantly.

ISSN 

0032-0943

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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