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Title 

Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1

Authors 

Ha Won JeongMi Ran KimKwang Hee SonMi Young HanJi Hong HaMatthieu GarnierLaurent MeijerByoung-Mog Kwon

Publisher 

Elsevier

Issue Date 

2000

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 10, no. 16, pp. 1819-1822

Keywords 

cyclin dependent kinasecyclin dependent kinase 4cyclin dependent kinase inhibitorenzyme inhibitioninhibition kineticscyclin D1enzyme inhibitors

Abstract 

A series of cinnamaldehydes was synthesized for the study of inhibitory activity against cyclin dependent kinases (CDKs). A couple of compounds selectively inhibited cyclin D1-CDK4 with an IC50 value of 7-18 μM.

ISSN 

0960-894X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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