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Title 

8-O-Methylsclerotiorinamine, Antagonist of the Grb2-SH2 Domain, Isolated from Penicillium multicolor

Authors 

Ji Youn NamHyae Kyeong KimJu Young KwonMi Young HanSung Uk KimKwang Hee SonByoung-Mog Kwon

Publisher 

American Chemical Society

Issue Date 

2000

Citation 

Journal of Natural Products, vol. 63, no. 9, pp. 1303-1305

Keywords 

8 o methylsclerotiorinaminegrowth factor receptor bound protein 2Src homology 2 proteindrug isolationnuclear magnetic resonance spectroscopyPenicilliumPenicillium multicolorprotein protein interactionisoquinolinesmolecular structure

Abstract 

A new secondary metabolite, 8-O-methylsclerotiorinamine (1), was isolated from a strain of Penicillium multicolor, and its structure was established using NMR spectroscopy and chemical evidence. The metabolite inhibited significantly the binding between the Grb2-SH2 domain and the phosphopeptide derived from the Shc protein and also blocked the protein - protein interactions of Grb2-Shc in cell-based experiments, with IC50 values of 5.3 and 50 μM, respectively.

ISSN 

0163-3864

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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