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Title 

Phellinsin A, a novel chitin synthases inhibitor produced by Phellinus sp. PL3

Authors 

Eui Il HwangBong Sik YunYoung Kook KimByoung Mog KwonHong Gi KimHyang Bok LeeWon Jin JeongSung Uk Kim

Publisher 

Nature Publishing Group

Issue Date 

2000

Citation 

Journal of Antibiotics, vol. 53, no. 9, pp. 903-911

Keywords 

acetic acid ethyl esteracetoneantifungal agentaromatic compoundbenzene derivativechitin synthaseenzyme inhibitorgalactosegamma lactone derivativemethanol

Abstract 

Phellinsin A, a novel chitin synthases inhibitor was isolated from the cultured broth of fungus PL3, which was identified as Phellinus sp. PL3. Phellinsin A was purified by solvent partition, silica gel, ODS column chromatographies, and preparative HPLC, consecutively. The structure of phellinsin A was assigned as a phenolic compound on the basis of various spectroscopic analyses including UV, IR, Mass, and NMR. Its molecular weight and formula were found to be 358 and C18H14O8, respectively. Phellinsin A selectively inhibited chitin synthase I and II of Saccharomyces cerevisiae with an IC50 value of 76 and 28 μg/ml, respectively, in our cell free assay system. This compound showed antifungal activity against Colletotrichum lagenarium, Pyricularia oryzae, Rhizoctonia solani, Aspergillus fumigatus, and Trichophyton mentagrophytes.

ISSN 

0021-8820

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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