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Title 

Interleukin-6-induced tyrosine phosphorylation of phospholipase C-γ1 in PC12 cells

Authors 

Young Han LeeSun Sik BaeJeong Kon SeoInpyo ChoiSung Ho RyuPann Gill Suh

Publisher 

Springer Verlag (Germany)

Issue Date 

2000

Citation 

Molecules and Cells, vol. 10, no. 4, pp. 469-474

Keywords 

interleukin 6PC12 cellsphospholipase C-γ1signal transductiontyrosine phosphorylation

Abstract 

Phospholipase C (PLC)-γ1 plays a pivotal role in the signal transduction pathway mediated by growth factors. In this study, we found that neurite outgrowth of pheochromocytoma (PC12) cells was significantly induced by interleukin-6 (IL-6). Stimulation of PC12 cells with IL-6 led to tyrosine phosphorylation of PLC-γ1 in a dose- and time-dependent manner. IL-6 stimulation also increased the hydrolysis of phosphatidylinositol 4,5-bisphosphate. Accumulation of total inositol phosphate as well as tyrosine phosphorylation of PLC-γ1 was inhibited by the pretreatment of protein kinase inhibitors such as genistein and staurosporine. These results suggest that PLC-γ1 may be involved in the signal transduction pathway of IL-6-induced PC12 cell differentiation.

ISSN 

1016-8478

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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