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Title 

Analysis of tnrA alleles which result in a glucose-resistant sporulation phenotype in Bacillus subtilis

Authors 

Byung Sik ShinSoo Keun ChoiIssar SmithSeung Hwan Park

Publisher 

American Society for Microbiology

Issue Date 

2000

Citation 

Journal of Bacteriology, vol. 182, no. 17, pp. 5009-5012

Keywords 

glucosealleleBacillus subtiliscarboxy terminal sequencegene activationgene activitygene expression regulationgenetic analysisnonhumanphenotype

Abstract 

Bacillus subtilis cells cannot sporulate in the presence of catabolites such as glucose. During the analysis of Tn10-generated mutants, we found that deletion of the C-terminal region of the tnrA gene, which encodes a global regulator that positively regulates a number of genes in response to nitrogen limitation, results in a catabolite-resistant sporulation phenotype. Analyses of nrg-lacZ and nasB-lacZ, which are activated by TnrA under nitrogen limitation, showed that C-terminally truncated TnrA activates nitrogen-regulated genes constitutively. The relief of catabolite repression of sporulation may result from the uncontrolled expression of the TnrA-regulated genes.

ISSN 

0021-9193

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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