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Title 

Cyclo(Dehydroala-l-Leu), an α-glucosidase inhibitor from Penicillium sp. F70614

Authors 

Oh Sung KwonSang Ho ParkBong Sik YunYu Ryang PyunChang Jin Kim

Publisher 

Nature Publishing Group

Issue Date 

2000

Citation 

Journal of Antibiotics, vol. 53, no. 9, pp. 954-958

Keywords 

1 (3 dimethylaminopropyl) 3 ethylcarbodiimidealpha galactosidasealpha glucosidasealpha glucosidase inhibitoralpha mannosidasebeta galactosidasebeta glucosidasecastanosperminecyclo(dehydroalanylleucine)dichloromethane

Abstract 

A diketopiperazine (1) has been isolated from the culture broth of Penicillium sp. F70614 and its structure has been determined to be cyclo(dehydroala-L-Leu) by various spectroscopic analyses. This compound selectively inhibited yeast α-glucosidase and porcine intestinal α-glucosidase with IC50 values of 35 and 50 μg/ml, respectively. However, it did not show significant inhibitory effects against almond β-glucosidase, Aspergillus α-galactosidase, Escherichia coli β-galactosidase and jack bean α-mannosidase.

ISSN 

0021-8820

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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