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Title 

Genomic organization and tissue-specific expression of rat urocortin

Authors 

Jung Hyun ParkYun Jung LeeShin Young NaKil Lyong Kim

Publisher 

Elsevier

Issue Date 

2000

Citation 

Neuroscience Letters, vol. 292, no. 1, pp. 45-48

Keywords 

raturocortingenomic organizationintronperipheral blood lymphocytesreverse transcription-polymerase chain reaction

Abstract 

The genomic organization of rat urocortin was determined using both cDNA and liver genomic DNA as templates for polymerase chain reactions. A single intron of 261 bp was found upstream to the ATG start codon, and the whole urocortin coding sequence was shown to be contained in a single exon. Relying on these results, oligonucleotide primers were designed, which can differentiate genomic DNA contamination from cDNA-derived signals in a reverse transcription-polymerase chain reaction. Tissue screening for urocortin expression revealed that the mid-brain is the major site of urocortin mRNA expression, and that other peripheral organs, including lymphoid tissues and peripheral blood lymphocytes, do not produce urocortin.

ISSN 

0304-3940

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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