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Title 

Inhibition of phospholipase cgamma1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla

Authors 

Ji Suk LeeJin Woong KimBo Yeon KimHyun Sun LeeJong Seog AhnYuan Shiun Chang

Publisher 

American Chemical Society

Issue Date 

2000

Citation 

Journal of Natural Products, vol. 63, no. 6, pp. 753-756

Keywords 

triterpene derivativeUncaria rhynchophyla extractestertriterpenecancer cellhuman cellcell culturecell divisioncell strain 3T3Uncaria rhynchophylla

Abstract 

Investigation of the hooks of Uncaria rhynchophylla resulted in isolation of six phospholipase Cγ1 (PLCγ1) inhibitors (1-6). The structures of these compounds were elucidated as pentacyclic triterpene esters by spectroscopic and chemical analysis. Three of them, namely uncarinic acids C (1), D (2), and E (3), are newly reported as natural products. All the compounds showed dose-dependent inhibitory activities against PLCγ1 in vitro with IC50 values of 9.5-44.6 μM and inhibited the proliferation of human cancer cells with IC50 values of 0.5-6.5 μg/mL.

ISSN 

0163-3864

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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