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Title 

pp60v-src reactivation inhibits serum-induced accumulation of inositol phosphates and phosphatidylethanol in tsNRK

Authors 

Bo Yeon KimJin Hee KimYoon Jeong HanSoon Cheol AhnDae Ook KangWon Keun OhHack Ryong KoHyun Sun LeeTae Ik MheenJong Seog Ahn

Publisher 

Taylor & Francis

Issue Date 

2000

Citation 

IUBMB Life, vol. 48, no. 1, pp. 85-89

Keywords 

phospholipase Cphospholipase Dprotein kinase CtsNRKv-src

Abstract 

In tsRSV-infected NRK (tsNRK) cells, pp60(v-src) reactivation by temperature-shift from a nonpermissive temperature, 39 °C, to a permissive one, 32 °C, induced the production of inositol phosphates (IPt) and phosphatidylethanol (PEt). This was accompanied by an increase in membrane- associated protein kinase C (PKC) activity in the absence of exogenous growth factors. However, with serum-stimulation, the amounts of IPt and PEt at 32 °C were less than those at 39 °C. Pretreatment with PKC inhibitors, Ro-31- 85220 and staurosporine, enhanced the accumulation of IPt but not of PEt at 32 °C. The tyrosine phosphorylation of phospholipase Cγ1 (PLCγ1) was increased either by serum or by pp60(v-src) reactivation. These results suggest that serum transduces its signal through PLCγ1 mediation, and that pp60(v-src), possibly through the PKC mediation, negatively affects serum- induced PLCγ1 activation.

ISSN 

1521-6543

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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