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Title 

Anti-apoptotic effects of terrein on etoposide-induced apoptosis of U937 human leukemia cells

 

Terrein의 etoposide에 의해 유도된 apoptosis 저해효과

Authors 

Choong Hwan LeeHo Jae LeeJin Hee KimHyun A KimYung Hee Kho

Publisher 

Korean Journal of Applied Microbiology and Biotechnology

Issue Date 

2000

Citation 

Korean Journal of Applied Microbiology & Biotechnology, vol. 28, no. 2, pp. 87-91

Keywords 

apoptosisinhibitorterreinetoposideU937 cells

Abstract 

In the course of screening for the substances inhibiting apoptosis of U937 human leukemia cell induced by etoposide, a fungal strain F80834 producing a high level of inhibitor was selected. The inhibitory substance was purified and identified as terrein by spectroscopic methods of UV, EI-MS, 1H-NMR, 13C-NMR and DEPT. Terrein showed inhibitory activity of caspase 3, a major protease of apoptosis cascade, with an IC50 value of 20 μg/ml after 7 hrs of treatment. It also showed protective effect against cell death with an IC50 value of 10 μg/ml on U937 cells induced by etoposide after 24 hrs of treatment, but did not show any cytotoxicity at the same condition without etoposide.

ISSN 

0257-2389

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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