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Title 

Korean red ginseng saponins with low ratios of protopanaxadiol and protopanaxatriol saponin improve scopolamine-induced learning disability and spatial working memory in mice

Authors 

Sung Ha JinJin Kyu ParkKi Yeul NamSue Nie ParkNoh Pal Jung

Publisher 

Elsevier

Issue Date 

1999

Citation 

Journal of Ethnopharmacology, vol. 66, no. 2, pp. 123-129

Keywords 

Korean red ginseng saponinPD/PT ratiomemoryscopolamine

Abstract 

The effects of two ginseng saponins having a different ratio of protopanaxadiol (PD) and protopanaxatriol saponins (PT) on the learning impairment induced by scopolamine, and learning and memory in mice were investigated in a passive avoidance task and a Morris water maze task. The ratio of PD and PT was 1.24 and 1.46, respectively. Before training, the ginseng saponins were administered intraperitoneally at doses of 50 and 100 mg/kg. The two saponins improved the scopolamine-induced learning impairment at different dosages in mice, 50 and 100 mg/kg, respectively. However, the two saponins did not show a favorable effect on learning and memory in normal mice. Korean red ginseng saponin with a low PD/PT ratio had an improving effect on spatial working memory, but the saponin with a high PD/PT ratio did not. This finding suggests that the PD/PT ratio of the ginseng saponins may be an important factor in the pharmacological role of red ginseng as a medicinal herb.

ISSN 

0378-8741

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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