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Title 

Inhibitory activity of stilbenes from medicinal plants on the expression of cell adhesion molecules on THP1 cells

Authors 

Kyung Seop AhnJung Hee KimSei Ryang OhShi Yong RyuHyeong Kyu Lee

Publisher 

Georg Thieme Verlag

Issue Date 

2000

Citation 

Planta Medica, vol. 66, no. 7, pp. 641-644

Keywords 

2,3,4',5 tetrahydroxystilbene 2 o beta dextro glucopyranoside3,5 dihydroxy 4' methoxystilbeneintercellular adhesion molecule 1stilbene derivativevascular cell adhesion molecule 1cell adhesionhuman cellmedicinal plantcell line

Abstract 

The inhibitory activity of stilbenes isolated from medicinal plants on cell adhesion molecules on the surface of THP-1 human monocytic cell lines was investigated. Among ten stilbenes tested, four stilbenes displayed a significant inhibitory activity on the expression of both intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). A cell-to-cell adhesion assay showed that 3,5-dihydroxy-4'-methoxystilbene and 2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucopyranoside as well as resveratrol blocked significantly TNF-α-inducing cell-cell adhesion between human umbilical vein endothelial cells (HUVEC) and THP-1 cells.

ISSN 

0032-0943

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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