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Title 

Inhibitory effect of coumarins on nitric oxide production in LPS-activated murine macrophages

 

쿠마린에 의한 raw 264.7 세포주의 nitric oxide 생성 저해활성

Authors 

Tae Cheol RhoHee Cheol ChoiBo Yeon KimYoung Ho KimJong Seog AhnYoung Kook KimHyun Sun Lee

Publisher 

Korean Society of Pharmacognosy

Issue Date 

1999

Citation 

Korean Journal of Pharmacognosy, vol. 30, no. 4, pp. 413-416

Keywords 

Ponciri Fructuscoumarinsnitric oxideRAW 264.7 cellslipopolysaccharide (LPS)

Abstract 

During the screening for inhibitors on nitric oxide (NO) production in LPS-activated murine macrophage, RAW 264.7 cells, two coumarins were isolated from chloroform extract of Ponciri Fructus. They were identified as imperatorin (10), phellopterin (11) on the basis of spectroscopic methods. The IC50 values for NO formatiom were about 5.4 μM and 35.0 μM, respectively, and then eleven coumarins were tested for the inhibitory effects on NO production in activated macrophages. All the test coumarins inhibited NO production in concentration-dependent manner and furanocoumarins (6-11) showed much more potent inhibitory effect than simple coumatins. Among the compounds examined xanthotoxin (8) was the most potent inhibitors of NO production (IC50=1.4 μM). Analysis of the structure-activity relationship among these coumarins led to the conclusion that the substitution of C-5 position in furanocoumarins reduces greatly their inhibitory potency although the substitution of C-8 does not almost affect it.

ISSN 

0253-3073

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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