상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Panax ginseng prevents apoptosis in hair follicles and accelerates recovery of hair medullary cells in irradiated mice

Authors 

Sung Ho KimKyu Shik JeongSi Yun RyuTae Hwan Kim

Publisher 

International Institute of Anticancer Research (IIAR)

Issue Date 

1998

Citation 

In Vivo, vol. 12, no. 2, pp. 219-222

Keywords 

Panax ginsengirradiationapoptosismedullary cellhair follicle

Abstract 

We studied the effect of the water fraction of Panax ginseng, one of traditional oriental medicine herbs on apoptosis and the formation of medullary cell in the hair follicles of irradiated mice. The hair follicle or its differentiated product, the hair, which represents a linear historical record follicular proliferative activity, could provide a biological indicator of the effect of radioprotecive drugs. Adult N:GP(s) mice with hair follicles synchronously, in the middle of the hair growth cycle received whole-body doses of γ-radiation. The hair follicles were analysed either 12 hours after irradiation with 2 Gy in the experiment on the apoptosis, or 3 days after irradiation with 3 Gy in the experiment on the forming medulla. The number of medullary cells per unit length (100 μm) were measured by H and E staining. Apoptosis was detected by a nonisotopic in situ DNA end-labeling (ISEL) technique and H and E stain applied to the serial histologic sections. Ginseng administration before irradiation resulted in a suppression of apoptosis, as shown by a reduced number of cells stained with ISEL for fragmented DNA, both I.P. (0.3 mg/head, p < 0.05) and P.O. (2mg/ml of drinking water, p < 0.05) treatment In addition, ginseng treatment was associated with an increase in the number of medullary cell per unit length as compared with the vehicle treated eaten mice (p < 0.001, I.P.; p < 0.05, P.O.). These results indicate that the water fraction of ginseng can exert a potent effect on the recovery of the hair follicles by its combined effects on proliferation and apoptosis of the cells in the hair follicle.

ISSN 

0258-851X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)