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Title 

Production of compactin from Penicillium sp. Y-8515

 

Penicillium sp. Y-8515에 의한 compactin 생산

Authors 

Joo Woong ParkJoo Kyung LeeTae Jong KwonYong Il ParkSang Mo Kang

Publisher 

Korean Journal of Applied Microbiology and Biotechnology

Issue Date 

2000

Citation 

Korean Journal of Applied Microbiology & Biotechnology, vol. 28, no. 5, pp. 291-297

Keywords 

Penicillium sp. Y-8515compactin productionfed-batch fermentation

Abstract 

Environmental Bioresources Lab., KRIBB, Yusong, Taejon 305-333, Korea -A strain producing high levels of compactin was isolated from soil and identified as Penicillium sp. Y-8515 based on the morphological characteristics and ribosomal RNA sequence analysis. Optimization of several different carbon and nitrogen sources for the effective production of compactin was performed resulting in the medium compositions containing 5%(w/v) glucose, 1.0% soybean meal, 0.5% yeast extract, 0.5% (NH4)2SO4, 0.25% NaH2PO4, 0.25% CaCO3. The fixed concentration of glucose (5%, w/v) and relatively lower concentrations (less than 2.5%, w/v) of soybean meal stimulated the transformation of the growth morphology from filamentous to pellet form. Comparing to that by filamentous form, the production of compactin by pellet form increased up to 1.5 folds. In a fed-batch fermentation, continuous feeding of the mixture of glucose and nitrogen source at the ratio of 10:1 showed 3.5-fold more production yield of compactin comparing to the batch mode.

ISSN 

0257-2389

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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