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Title 

Cytotoxic constituents from Notopterygium incisum

Authors 

Nguyen Hai NamHa Thi Thanh HuongHwan Mook KimByung Zun Ahn

Publisher 

Korean Society of Pharmacognosy

Issue Date 

2000

Citation 

Korean Journal of Pharmacognosy, vol. 31, no. 1, pp. 77-81

Keywords 

cinnamatecytotoxicityfalcarindioluranocoumarinnotopterygium incisumumbeliferae

Abstract 

The MeOH extract of Notopterygium incisum showed a strong cytotoxicity against B16 murine melanoma cell line. From this extract three furanocoumarins including bergamottin, isoimperatorin, notopterol and one polyacetylenic compound (falcarindiol) together with one phenylpropanoid (caffeic acid methyl ester) and one triterpenoid (pregnenolone) were isolated. The isolated compounds were evaluated for cytotoxic activity against four kinds of cancer cell lines, e.g. P388 (murine lymphocytic leukemia), B16 (murine melanoma), A549 (human lung carcinoma) and SK-OV-3 (human ovarian cancer). Among the isolates, falcarindiol and caffeic acid methyl ester expressed a significant antiproliferative activity against all tested cell lines.

ISSN 

0253-3073

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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