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Title 

Abnormal synaptic organization between granule cells and Purkinje cells in the new ataxic mutant mouse, pogo

Authors 

Young Gil JeongByung Hwa Hyun

Publisher 

Elsevier

Issue Date 

2000

Citation 

Neuroscience Letters, vol. 294, no. 2, pp. 77-80

Keywords 

abnormal synapseataxic mutantcerebellumectopic spineelectron microscopyparallel fiberpurkinje cell dendritic spinegranule cellmousemouse strain

Abstract 

The pogo mouse is a new ataxic mutant derived from the Korean wild mouse. The pathological manifestations include difficulty in maintaining normal posture and the inability to walk straight. The ataxia becomes apparent at about 2 weeks of age. Electron microscopic studies of the pogo/pogo homozygous cerebellum, revealed that the ectopic spines emanating from the primary dendrite of Purkinje cells were observed. Major difference between pogo/pogo homozygous and non-affected pogo/+ heterozygous was the synaptic organization of the molecular layer. Parallel fiber varicosities were larger than normal and a single fiber often established synaptic contacts with up to four dendritic spines of a Purkinje cell. This correlation between the presence of altered synaptic organization in the cerebellum and ataxia in pogo/pogo mutant mice warrants further investigation.

ISSN 

0304-3940

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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