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Title 

5,6-dinitrophenyl and 5-aminophenyl-6-nitrophenyl analogues of the acat inhibitor 5,6-diphenyl-3-alkylaminopyridazines

Authors 

Lucio TomaDonatella NavaGiuseppe CelentanoMaria Paola GiovannoniVittorio Dal PiazByoung-Mog KwonMi Kyung KimYoung Kook KimDaniela Barlocco

Publisher 

Elsevier

Issue Date 

2000

Citation 

Heterocycles, vol. 53, no. 12, pp. 2709-2718

Keywords 

cholesterol acyltransferase inhibitor

Abstract 

A series of dinitro and monoamino-mononitro analogues of the 5,6-diphenyl-3-alkylaminopyridazines were synthesized and their structure was assigned on the basis of mono and bidimensional NMR experiments. Their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. Theoretical studies were performed to correlate the activity of the compounds to their structural features.

ISSN 

0385-5414

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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