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Title 

Curdlan gels as protein drug delivery vehicles

Authors 

Beom Soo KimIn Duck JungJong Sik KimJung Heon LeeIn Young LeeKyung Bok Lee

Publisher 

Springer Verlag (Germany)

Issue Date 

2000

Citation 

Biotechnology Letters, vol. 22, no. 14, pp. 1127-1130

Keywords 

curdlangelhydroxyethylationprotein drug deliveryureadrug delivery systemdrug releaseprotein secretion

Abstract 

The use of curdlan, a natural β-1,3-glucan, in protein drug delivery vehicles was studied by carrying out in vitro release studies with curdlan gels containing bovine serum albumin (BSA) as a model protein. Addition of urea (8 M) decreased the gel formation temperature to 37 °C. Curdlan was hydroxyethylated in order to form gels under mild conditions such as physiological temperature and pH. In gels formed in 8 M urea solution, urea was almost released after 2 h while B SA was completely released after 45-100 h. The total time for complete release of BSA increased with curdlan concentration within gels. The strength of hydroxyethylated curdlan gels (385.7 dyne cm-2) was weaker than that of curdlan gels formed in 8 M urea solution (6277 dyne cm-2).

ISSN 

0141-5492

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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