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Title 

Inhibitory effect of triterpenes from Crataegus pinatifida on HIV-I protease

Authors 

Byung Sun MinHyun Ju JungJun Sung LeeYoung Ho KimSong Hae BokChao Mei MaNorio NakamuraMasao HattoriKi Hwan Bae

Publisher 

Georg Thieme Verlag

Issue Date 

1999

Citation 

Planta Medica, vol. 65, no. 4, pp. 374-375

Keywords 

proteinasetriterpeneunclassified drugursolic acidcarbon nuclear magnetic resonancecrataegusdrug isolationfractionationhigh performance liquid chromatographyhuman immunodeficiency virus 1

Abstract 

The methanol extracts of the leaves of Crataegus pinnatifida showed potent inhibitory activities against HIV-1 protease at a concentration of 100 μg/ml. The subsequent fractionation and isolation of the extract gave two active corn pounds. Their structures were identified as uvaol (1) and ursolic acid (2) by spectral data. These active compounds inhibit HIV 1 protease with IC50 values of 5.5 and 8.0 μM, respectively.

ISSN 

0032-0943

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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