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Title 

Dietary hematein ameliorates fatty streak lesions in the rabbit by the possible mechanism of reducing VCAM-1 and MCP-1 expression

Authors 

Goo Taeg OhJae Hoon ChoiJung Joo HongDae Young KimSae Bom LeeJu Ryoung KimChul Ho LeeByung Hwa HyunSei Ryang OhSong Hae BokTae Sook Jeong

Publisher 

Elsevier

Issue Date 

2001

Citation 

Atherosclerosis, vol. 159, no. 1, pp. 17-26

Keywords 

hemateinatherosclerosisMCP-1VCAM-1

Abstract 

Hematein is a compound isolated from Caesalpinia sappan that has been used in oriental medicine as both an analgesic and an anti-inflammatory agent. In this study, we examined the anti-atherogenic potential of hematein using cholesterol-fed New Zealand White (NZW) rabbits. NZW rabbits were divided into a hematein-supplemented (0.05% in diet) group (n = 6), a probucol-supplemented (0.25% in diet) group (n = 6), and a control group (n = 6). After 8 weeks of treatments, the extent of the atherosclerotic lesions was significantly reduced in the hematein-supplemented group and the probucol-supplemented group without changing plasma lipoprotein levels. Hematein and probucol prevented the up-regulation of the vascular cell adhesion molecule-1 (VCAM-1) expression on the descending aorta induced by cholesterol diet. In culture, hematein also significantly inhibited the secretion of soluble VCAM-1 and of monocyte chemotactic protein-1 (MCP-1) respectively induced by tumor necrotic factor α (TNF-α) and mildly oxidized low density lipoprotein in human umbilical vein endothelial cell (HUVEC) culture. Also, hematein inhibited monocyte adhesion to endothelial cell and the activation of NF-κB in HUVECs stimulated with TNF-α. The results of the present study suggest that the anti-atherogenic effect of hematein is not related to control of the plasma lipid profile but probably related to the inhibition of VCAM-1 and MCP-1 expression resulting in an amelioration of lesion development in the rabbit.

ISSN 

0021-9150

Link 

http://dx.doi.org/10.1016/S0021-9150(01)00464-6

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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