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Title 

A sesquiterpene lactone, costunolide, from Magnolia grandiflora inhibits NF-κB by targeting IκB phosphorylation

Authors 

Tae Hyeon KooJeong Hyung LeeYun Joo ParkYoung Soo HongHang Sub KimKyu Won KimJung Joon Lee

Publisher 

Georg Thieme Verlag

Issue Date 

2001

Citation 

Planta Medica, vol. 67, no. 2, pp. 103-107

Keywords 

magnolia grandifloramagnoliaceaecostunolideinducible nitric oxide synthaseNF-κBIκB

Abstract 

A sesquiterpene lactone, costunolide (CTN), was identified from Magnolia grandiflora together with parthenolide (PTN) by its strong inhibition of LPS-induced NF-κB activation. CTN, which showed more potent inhibition than PTN in the NF-κB activation, strongly suppressed nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells. RT-PCR and Western blot analyses demonstrated that CTN suppressed the expression of iNOS mRNA and protein in a dose-dependent manner. CTN also significantly inhibited LPS-induced DNA-binding activity of NF-κB as well as the LPS-induced degradation of IκB-α and -β. Furthermore, CTN inhibited LPS-induced phosphorylation of IκB-α. These findings support that CTN inhibits NO production by down-regulating iNOS expression, at least, in part through the inhibition of IκBs' phosphorylation and degradation, which are essential for the activation of NF-κB.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2001-11503

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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