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Title 

Kaurane diterpenes from Isodon japonicus inhibit nitric oxide and prostaglandin E2 production and NF-κB activation in LPS-stimulated macrophage RAW264.7 cells

Authors 

Bang Yeon HwangJeong Hyung LeeTae Hyeon KooHang Sub KimYoung Soo HongJai Seup RoKyong Soon LeeJung Joon Lee

Publisher 

Georg Thieme Verlag

Issue Date 

2001

Citation 

Planta Medica, vol. 67, no. 5, pp. 406-410

Keywords 

isodon japonicuslabiataekaurane diterpenesnitric oxideprostaglandin E2NF-κB

Abstract 

A methanolic extract of the whole plant of Isodon japonicus (Labiatae) showed potent inhibition on the LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW264.7 cells. Four known kaurane diterpenes were isolated by activity-guided fractionation and their structures were identified as kamebanin (1), kamebacetal A (2), kamebakaurin (3), excisanin A (4). All compounds also inhibited the LPS-induced NF-κB activation as assessed by NF-κB reporter assay and electrophoretic mobility shift assay (EMSA). Compounds 2-4 showed comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-κB without affecting cell viability. These results suggest that kaurane diterpenes could exert their inhibitory effects on the production of NO and PGE2 through the suppression of NF-κB activation, and be partially responsible for the anti-inflammatory activities of the genus Isodon.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2001-15808

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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