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Title 

Isolation and phylogeny of new endogenous retroviral sequences belonging to the HERV-F family

Authors 

Joo Young ChoiJun Seop KimJoo Mi LeeByung Hwa HyunHeui Soo Kim

Publisher 

Mary Ann Liebert

Issue Date 

2001

Citation 

AIDS Research and Human Retroviruses, vol. 17, no. 4, pp. 367-370

Keywords 

gene amplificationgene sequencehuman immunodeficiency virus infectionnucleotide sequencephylogenyendogenous retrovirusesmolecular sequence datasequence analysis, DNA

Abstract 

A new human endogenous retroviral family (HERV-F) has been identified from human chromosome 7q31.1-q31.3 that was identical to the XA34 cDNA clone isolated from a human glioma cDNA library with an ERV-9 env probe. We investigated pol gene sequences of the HERV-F family from a human monochromosomal DNA panel and analyzed these with HERV-F. The pol gene sequences of the HERV-F family were detected on chromosomes 3, 6, 7, 10, 11, 14, 19, 20, X, and Y as examined by PCR. Thirty-six pol gene sequences identified from the human chromosomes have a high degree of sequence similarity (80-99%) with that of the HERV-F. Phylogenetic analysis of pol gene sequences distinctively showed four groups, indicating that the HERV-F family could be amplified at least four times after the original integration into the human genome or represent integration events separately during hominid evolution. One clone (HFY-3) on chromosome Y shared 100% sequence identity with a clone (HF19-2) on chromosome 19, and a clone (HF20-6) on chromosome 20 suggests either a recent retrotransposition or a chromosomal translocation. The history of endogenous retroviral sequences may contribute to an understanding of evolutionary change in human genomes.

ISSN 

0889-2229

Link 

http://dx.doi.org/10.1089/08892220150503735

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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