상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Inhibitory Effect of 2'-O-Benzoylcinnamaldehyde on Vascular Endothelial Cell Proliferation and Migration

Authors 

Ji Young ParkByoung Mog KwonSung Kun ChungJae Ho KimChoun Ki Joo

Publisher 

Karger

Issue Date 

2001

Citation 

Ophthalmic Research, vol. 33, no. 2, pp. 111-116

Keywords 

2'-O-benzoylcinnamaldehydebasic fibroblast growth factorcorneal angiogenesisvascular endothelial cellvascular endothelial growth factor

Abstract 

Purpose: To evaluate the inhibitory effect of the farnesyl transferase inhibitor 2′-O-benzoylcinnamaldehyde (CB 2′-ph) on proliferation and migration of vascular endothelial cells. Methods: Bovine lens epithelial cells, bovine corneal endothelial cells, bovine keratocytes, bovine aortic endothelial cells (BAECs) and human umbilical vein endothelial cells (HUVECs) were treated with CB 2′-ph to determine its cell type specificity and antiproliferative effect. For inhibition of vascular endothelial cell growth factor (VEGF)- or basic fibroblast growth factor (bFGF)-induced proliferation of HUVECs, these cells were treated with various concentrations of CB 2′-ph. To assess the proliferation, MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide) assay was used. The migration assay was also performed to determine the effect of CB 2′-ph on HUVECs. The distance of HUVEC outgrowth was measured from the scraped edge of a monolayer after treatment with CB 2′-ph concentrations of 0, 1.5 and 2.5g/ml for 24, 48 and 72 h. Results: The CB 2′-ph had an inhibitory effect on all tested types of cell proliferation but only HUVEC and BAEC proliferation was specifically inhibited in a dose-dependent manner. In addition, CB 2′-ph inhibited VEGF- or bFGF-induced proliferation and migration of HUVECs in a dose-dependent manner. Conclusions: These results indicate that CB 2′-ph, a farnesyl transferase inhibitor is thought to be an effective inhibitor of vascular endothelial cell proliferation and migration.

ISSN 

0030-3747

Link 

http://dx.doi.org/10.1159/000055654

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)