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Title 

Tumor necrosis factor receptor superfamily 12 may destabilize atherosclerotic plaques by inducing matrix metalloproteinases

Authors 

S H KimW H LeeB S KwonGoo Taeg OhY H ChoiJ E Park

Issue Date 

2001

Citation 

Japanese Circulation Journal, vol. 65, no. 2, pp. 136-138

Keywords 

atherosclerosismatrix metalloproteinasetumor necrosis factor receptor superfamily

Abstract 

Immunohistochemical staining of human atherosclerotic plaques revealed expression of the tumor necrosis factor receptor superfamily (TNFRSF) 12 in regions rich in macrophage/foam cells. The role of TNFRSF12 in the functioning of monocytes in relation to atherogenesis was investigated by analysis of cellular events after stimulation of TNFRSF12 in a human macrophage-like cell line, THP-1. Activation of the THP-1 cells on plates coated with monoclonal antibody against TNFRSF12 induced the expression of matrix metalloproteinases (MMPs) -1, -9, and -13. Furthermore, the expression patterns of TNFRSF12 and the MMPs overlapped in atherosclerotic plaques. Signaling of TNFRSF12 may thus contribute to the induction of extracellular matrix degrading enzymes in macrophages.

ISSN 

0047-1828

Link 

http://dx.doi.org/10.1253/jcj.65.136

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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