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Title 

Negative regulation of yy1 transcription factor on the dynamin i gene promoter

Authors 

Ji Yun YooMoon Jin JeongSang Seop LeeKyung Im LeeByoung Mog KwonYoung Mee ParkMi Young Han

Publisher 

Elsevier

Issue Date 

2001

Citation 

Biochemical and Biophysical Research Communications, vol. 283, no. 2, pp. 340-343

Keywords 

dynamin IpromoterYY1

Abstract 

Dynamin I is highly expressed in brain and plays a critical role in clathrin-mediated endocytosis and synaptic vesicle recycling. To elucidate the molecular mechanism by which expression of dynamin I is tissue-specifically regulated, we previously cloned and characterized the promoter of the mouse dynamin I gene and suggested that there is a negative regulatory element in this promoter region. In the present study, we showed that YY1 binds to this negative regulatory element located at -111 to -107 by using the EMSA and supershift analyses. Cotransfection experiment using an YY1 expression vector revealed that YY1 exerts a repressive role on the dynamin I gene promoter activity. These results demonstrate that transcription factor YY1 negatively regulates dynamin I expression via binding to the negative regulatory element.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1006/bbrc.2001.4784

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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