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Title 

Rkp1/Cpc2, a fission yeast rACK1 homolog, is involved in actin cytoskeleton organization through protein kinase C, Pck2, signaling

Authors 

Mi Sun WonSeung Kiel ParkKwang Lae HoeYoung Joo JangKyung Sook ChungDong Uk KimHyung Bae KimHyang Sook Yoo

Publisher 

Elsevier

Issue Date 

2001

Citation 

Biochemical and Biophysical Research Communications, vol. 282, no. 1, pp. 10-15

Keywords 

Rkp1Cpc2Pck2actin cytoskeletonS. pombe

Abstract 

The Rkp1/Cpc2, a fission yeast RACK1 homolog, interacted with Pck2, one of the known PKC homologs, in vivo and in vitro. The rkp1-deletion mutants (Δrkp1) are elongated and the pck2-deletion mutant (Δpck2) showed abnormal morphology. The double-deletion mutant (Δrkp1Δpck2) showed more aberrant cell shapes and was sensitive to high salt concentration. Both Δrkp1 and Δpck2 cells were sensitive to latrunculin B (Lat B) which inhibits actin polymerization. The cells expressing the human RACK1 homolog complemented the latrunculin B sensitivity of Δrkp1 indicating that human RACK1 is a functional homolog of Rkp1/Cpc2. We propose that Rkp1/Cpc2 may function as a receptor for Pck2 in the regulation of actin cytoskeleton organization during cell wall synthesis and morphogenesis of Schizosaccharomyces pombe.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1006/bbrc.2001.4535

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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