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Title 

Inhibition of cytokine-induced vascular cell adhesion molecule-1 expression; possible mechanism for anti-atherogenic effect of Agastache rugosa

Authors 

Jung Joo HongJae Hoon ChoiSei Ryang OhHyeong Kyu LeeJae Hak ParkKun Yeong LeeJung Jae KimTae Sook JeongGoo Taeg Oh

Publisher 

Elsevier

Issue Date 

2001

Citation 

FEBS Letters, vol. 495, no. 3, pp. 142-147

Keywords 

atherosclerosistilianinvascular cell adhesion molecule-1macrophagenuclear factor-κBagastache rugosa

Abstract 

Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) play an important role during the early stages of atherogenesis. Agastache rugosa has an anti-atherogenic effect in low density lipoprotein receptor -/- mice. Moreover, A. rugosa reduced macrophage infiltration and VCAM-1 expression has been localized in aortic endothelium that overlies early foam cell lesions. This study ascertained that tilianin (100 μM), a major component of A. rugosa, inhibits the tumor necrotic factor-α (TNF-α)-induced expression of VCAM-1 by 74% in cultured human umbilical vein endothelial cells (HUVECs). Also, tilianin (100 μM) reduced TNF-α-induced activation of nuclear factor-κB in HUVECs.

ISSN 

0014-5793

Link 

http://dx.doi.org/10.1016/S0014-5793(01)02379-1

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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