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Title 

Up-regulation of ninjurin expression in human hepatocellular carcinoma associated with cirrhosis and chronic viral hepatitis

Authors 

Jae Wha KimAe Ran MoonJoo Heon KimSun Young YoonGoo Taeg OhYong Kyung ChoeIn Seong Choe

Publisher 

Springer Verlag (Germany)

Issue Date 

2001

Citation 

Molecules and Cells, vol. 11, no. 2, pp. 151-157

Keywords 

chronic Hepatitiscirrhotic liver tissueshepatocellular carcinomaliver regenerationup-regulation of ninjurin expressionNINJ1 protein, humanchronic hepatitishumanliver cell carcinomaliver cirrhosis

Abstract 

The cDNA clones, which were highly expressed in liver tissues of hepatocellular carcinoma (HCC) patients, were identified using dot hybridization and reconfirmed by Northern blot analysis. One of the clones, ninjurin (nerve injury induced protein), showed a much higher expression level in the liver tissue of HCC patients than in normal liver tissue. Interestingly, the presence of ninjurin mRNA transcripts was detected with high intensity in HCC tissues when combined with viral infection and cirrhosis, but not with a normal liver or HCC tissue unrelated with viral infection and cirrhosis. We produced a N-terminal part of recombinant ninjurin protein, as well as a monoclonal antibody specific to this polypeptide. The intensity of immunohistochemical staining of the liver tumor tissue, and regenerating tissue for the ninjurin protein, was stronger than that of normal liver tissue. These results suggest that ninjurin may play an important role in the development of HCC combined with cirrhosis and viral infection.

ISSN 

1016-8478

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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