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Title 

The Neuron Restrictive Silencer Factor Can Act as an Activator for Dynamin I Gene Promoter Activity in Neuronal Cells

Authors 

Ji Yun YooMoon Jin JeongSang Seop LeeKyung Im LeeByoung Mog KwonDong Sun KimYoung Mee ParkMi Young Han

Publisher 

Elsevier

Issue Date 

2001

Citation 

Biochemical and Biophysical Research Communications, vol. 283, no. 4, pp. 928-932

Keywords 

dynamin IpromoterNRSENRSFNS20Y cells

Abstract 

The neuron restrictive silencer element (NRSE) has been identified in several neuronal genes and confers neuron specificity by silencing transcription in nonneuronal cells. We have previously reported that Sp1 and an NF-κB-like element (NE-1) are required for the promoter activity of mouse dynamin I gene. In the present study, we found that the upstream regulatory region of the dynamin I promoter has an NRSE-like sequence and showed that neuron restrictive silencer factor (NRSF) binds to this element in neuronal cells as well as in nonneuronal cells. We also showed that NRSF activates the promoter activity of dynamin I gene in neuronal cells. From the results in this study, we suggest that NRSE might be involved in the neuron restriction of dynamin I expression, and NRSF could act as an activator for promoter activity of dynamin I gene in neuronal cells.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1006/bbrc.2001.4857

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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