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Title 

Syntheses of certain 3-Aryl-2-propenoates and evaluation of their cytotoxicity

Authors 

Nguyen-Hai NamYoung Jae YouYong KimDong Ho HongHwan Mook KimByung Zun Ahn

Publisher 

Elsevier

Issue Date 

2001

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 11, no. 9, pp. 1173-1176

Keywords 

ethyl 3 [2 (1,4 dihydroxy 9,10 dione)anthracenyl] 2 propenoic acidethyl 3 [2 (1,4 dimethoxy 5,8 dione)naphthalenyl] 2 propenoic acidmethyl 3 [2 (1,4 dihydroxy 9,10 dione)anthracenyl] 2 propenoic acidmethyl 3 [2 (1,4 dimethoxy 5,8 dione)naphthalenyl] 2 propenoic aciddrug cytotoxicitydrug synthesis

Abstract 

A series of 3-aryl-2-propenoates including cinnamates, (E)-methyl/ethyl 3-[2-(1,4-dimethoxy-5,8-dione)naphthalenyl]-2-propenoates (8ba, 8bb) and (E)-methyl/ethyl 3-[2-(1,4-dihydroxy-9,10-dione)anthracenyl]-2-propenoates (9aa, 9ab) was synthesized and evaluated for antitumor cytotoxicity. It was found that the ortho- or para-dihydroxy funtionality on the aryl ring was essential for the cytotoxicity of cinnamates. Compounds 8ba, 8bb and 9aa, 9ab showed potent cytotoxicity against various tumor cell lines.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/S0960-894X(01)00165-2

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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