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Title 

Effect of genistein analogs on oxygen radical production in leukocytes stimulated by unopsonized zymosan

Authors 

J YunSei Ryang OhHyeong Kyu LeeI M ChangK TakatsuY P YunK R MinY Kim

Publisher 

Georg Thieme Verlag

Issue Date 

2001

Citation 

Planta Medica, vol. 67, no. 3, pp. 274-276

Keywords 

genisteinoxygen radicalzymosandrug effectleukocytes

Abstract 

Effects of genistein analogs on oxygen radical production have been analyzed in human neutrophils, human monocytes or murine macrophages Raw264.7 stimulated with unopsonized zymosan by lucigenin- and luminol-enhanced chemiluminescence assays. Genistein exhibited IC50 values of 10.7-11.5 μM on the oxygen radical production in human neutrophils, 10.9-11.0 μM in human monocytes, and 14.8-27.3 μM in Raw264.7 cells. Orobol, a genistein analog with an additional hydroxy group at the 3' position, exhibited IC50 values of 3.0-3.3 μM on the oxygen radical production in human neutrophils, 2.8-3.1 μM in human monocytes, and 1.5-3.9 μM in Raw264.7 cells. Genistin and sophoricoside are genistein glycosides with a glucose moiety at 7 or 4′ position, respectively. The genistein glycosides exhibited 23-37% inhibitory effects at 100 μM on the oxygen radical production.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2001-12002

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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