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Title 

Inhibition of telomerase activity by fungus metabolites, CRM646-A and thielavin B

Authors 

K TogashiH R KoJong Seog AhnH Osada

Publisher 

Japan Society for Bioscience, Biotechnology and Agrochemistry

Issue Date 

2001

Citation 

Bioscience Biotechnology and Biochemistry, vol. 65, no. 3, pp. 651-653

Keywords 

screeningtelomeraseCRM646-Athielavin Breverse transcriptase

Abstract 

We performed a screening program to identify telomerase inhibitors from our drug source obtained from fungus fermentations, and found that two compounds, CRM646-A and thielavin B, inhibited telomerase activity at doses of 3.2 and 32 μM, respectively. These compounds also inhibited the activity of viral reverse transcriptase at almost the same dose levels which inhibited telomerase activity.

ISSN 

0916-8451

Link 

http://dx.doi.org/10.1271/bbb.65.651

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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