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Title 

Synthesis and in vitro evaluation of 3-substituted-1-azaanthraquinones

Authors 

Hee Soon LeeSeoung Soo HongYoung Ho Kim

Publisher 

Elsevier

Issue Date 

1996

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 6, no. 8, pp. 933-936

Keywords 

drug synthesis

Abstract 

In the course of developing novel antitumor agents, we synthesized 3-substituted-1-azaanthraquinones incorporating the alkylating or latent alkylating substituents as potential antitumor agents. The most active compound 4 exhibited cytotoxic activity comparable to that of doxorubicin. The compounds 3-8 retained much of their activity against the doxorubicin-resistant cell line (MCF7/R).

ISSN 

0960-894X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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