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Title 

Preparation of Enantiomerically Pure (R)-2-Butyryloxymethylglycidol by Lipase-Catalyzed Asymmetric Hydrolysis

Authors 

Young Bae SeuTaeg Kyeong LimChang Jin KimSun Chul Kang

Publisher 

Elsevier

Issue Date 

1995

Citation 

Tetrahedron : Asymmetry, vol. 6, no. 12, pp. 3009-3014

Keywords 

2 butyryloxymethylglycidolunclassified drugdrug synthesisenantiomerhydrolysispriority journal

Abstract 

Optically active epoxy alcohol, (R)-2-butyryloxymethylglycidol 3 which is the precursor of a tert-alcohol chiral building block was obtained in high enantiomeric purity, 98.7% e.e., by lipase-catalyzed asymmetric hydrolysis using a phosphate buffer and organic co-solvent system in 95% of chemical yield.

ISSN 

0957-4166

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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