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Title 

Enzymatic conversion of rifamycin B in a rotating packed disk reactor

Authors 

Bong Hyun ChungHo Nam ChangMoon Hi Han

Issue Date 

1986

Citation 

Journal of Fermentation Technology, vol. 64, no. 4, pp. 343-345

Abstract 

The biological conversion of rifamycin B to rifamycin S was attempted using immobilized rifamycin B oxidase in a rotating packed disk reactor (RPDR). Humicola sp. (ATCC 20620) was treated with acetone and the cell powder was immobilized with cellulose acetate. The three phase reaction involving oxygen, substrate, and the immobilized enzyme beads was done in the RPDR. The physical strength of the immobilized enzyme beads was very good and was suitable as packing material in RPDR. The optimum submergence in the RPDR was 0.5 and the rotating speed of the disk did not affect the conversion very much. In continuous operation as the residence time increased, the conversion of rifamycin B increased, but the productivity decreased.

ISSN 

0385-6380

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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