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Title 

Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic acat and aortic vcam-1 and mcp-1 in high cholesterol-fed rabbits

Authors 

Chul Ho LeeTae Sook JeongYang Kyu ChoiByung Hwa HyunGoo Taeg OhEun Hee KimJu Ryoung KimJang Il HanSong Hae Bok

Publisher 

Elsevier

Issue Date 

2001

Citation 

Biochemical and Biophysical Research Communications, vol. 284, no. 3, pp. 681-688

Keywords 

naringinnaringeninfatty streakACATMCP-1VCAM-1

Abstract 

The anti-atherogenic effects of the citrus flavonoids, naringin and naringenin, were evaluated in high cholesterol-fed rabbits. At 3 months of age, 30 male New Zealand White (NZW) rabbits were divided into three groups (n=10 per group). The rabbits were fed a 1% cholesterol diet alone (control group) or a diet supplemented with either 0.1% naringin or 0.05% naringenin for 8 weeks. The plasma lipoprotein levels, total cholesterol, triglyceride, and high-density lipoprotein showed no significant differences in the control and experimental groups. Hepatic acyl-CoA: cholesterol acyltransferase (ACAT) activity was slightly low in naringin (5.0%)- and naringenin (15.0%)-fed rabbits, compared to control group. The aortic fatty streak areas were significantly lower in both the naringin (19.2 ± 5.6%)- and naringenin (18.1 ± 6.5%)-supplemented groups than in the control group (60.4 ± 14.0%). The expression levels of vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemotactic protein-1 (MCP-1), by semiquantitative RT-PCR analysis of the thoracic aorta, were significantly lower in the flavonoids supplemented groups than in the control group. These results suggest that the anti-atherogenic effect of the citrus flavonoids, naringin and naringenin, is involved with a decreased hepatic ACAT activity and with the downregulation of VCAM-1 and MCP-1 gene expression.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1006/bbrc.2001.5001

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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