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Title 

Differential inheritance modes of DNA methylation between euchromatic and heterochromatic DNA sequences in ageing fetal bovine fibroblasts

Authors 

Yong Kook KangDeog Bon KooJung Sun ParkYoung Hee ChoiKyung Kwang LeeYong Mahn Han

Publisher 

Elsevier

Issue Date 

2001

Citation 

FEBS Letters, vol. 498, no. 1, pp. 1-5

Keywords 

ageingmethylationepigenetic modificationeuchromatinheterochromatin

Abstract 

To elucidate overall changes in DNA methylation occurring by inappropriate epigenetic control during ageing, we compared fetal bovine fibroblasts and their aged neomycin-resistant versions using bisulfite-PCR technology. Reduction in DNA methylation was observed in euchromatic repeats (18S-rRNA/art2) and promoter regions of single-copy genes (the cytokeratin/β-lactoglobulin/interleukin-13 genes). Contrastingly, a stable maintenance of DNA methylation was revealed in various heterochromatic sequences (satellite I/II/alphoid and Bov-B). The differential inheritance mode of DNA methylation was confirmed through the analysis of individual neomycin-resistant clones. These global, multi-locus analyses provide evidence on the tendency of differential epigenetic modification between genomic DNA regions during ageing.

ISSN 

0014-5793

Link 

http://dx.doi.org/10.1016/S0014-5793(01)02472-3

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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