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Title 

Binding and regulation of HIF-1α by a subunit of the proteasome complex, PSMA7

Authors 

Sa Yeon ChoYoun Jeong ChoiJeong Min KimSeong Tae JeongJae Hoon KimSeung Ho KimSeong Eon Ryu

Publisher 

Elsevier

Issue Date 

2001

Citation 

FEBS Letters, vol. 498, no. 1, pp. 62-66

Keywords 

hypoxiahypoxia-inducible factor-1αproteasomePSMA7

Abstract 

The hypoxia-inducible factor-1α (HIF-1α) is an important transcription factor for cellular responses to oxygen tension. It is rapidly degraded under normoxic conditions by the ubiquitin-dependent proteasome pathway. Here we report a critical role of the 20S proteasome subunit PSMA7 in HIF-1α regulation. PSMA7 was found to interact specifically with two subdomains of HIF-1α. PSMA7 inhibited the transactivation function of HIF-1α under both normoxic and hypoxia-mimicking conditions. In addition, we show that the PSMA7-mediated regulation of HIF-1α activity is associated with the proteasome pathway.

ISSN 

0014-5793

Link 

http://dx.doi.org/10.1016/S0014-5793(01)02499-1

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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