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Title 

Genistein, a soy isoflavone, is a potent α-glucosidase inhibitor

Authors 

Dong Sun LeeSang Han Lee

Publisher 

Elsevier

Issue Date 

2001

Citation 

FEBS Letters, vol. 501, no. 1, pp. 84-86

Keywords 

genisteinα-glucosidase inhibitorenzyme kinetics

Abstract 

Genistein is an isoflavone that is known to be contained in soybean. It was proved that genistein plays a pivotal role in homeostasis in the human body. In the course of screening for useful α-glucosidase inhibitors, we isolated and identified genistein as a candidate for α-glucosidase inhibitor from fermentation broths of a Streptomyces sp. Genistein was shown to be a reversible, slow-binding, non-competitive inhibitor of yeast α-glucosidase with a Ki value of 5.7 × 10-8 M when the enzyme mixture was pretreated with genistein. These results show a possibility that genistein could be a useful tool for metabolic disorders.

ISSN 

0014-5793

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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