상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Inhibitory activity for chitin synthase II from Saccharomyces cerevisiae by tannins and related compounds

Authors 

Eui Il HwangByung Tae AhnHyang Bok LeeYoung Kook KimKyong Soon LeeSong Hae BokYoung Tae KimSung Uk Kim

Publisher 

Georg Thieme Verlag

Issue Date 

2001

Citation 

Planta Medica, vol. 67, no. 6, pp. 501-504

Keywords 

euphorbia pekinensiseuphorbiaceaechitin synthase IIchitin synthase II inhibitortanninsantifungal agents

Abstract 

In the course of search for potent inhibitors of chitin synthase II from natural resources, seven tannins and related compounds were isolated from the aerial part of Euphorbia pekinensis and identified as gallic acid, methyl gallate, 3-O-galloyl-(-)-shikimic acid, corilagin, geraniin, quercetin-3-O-(2″-O-galloyl)-β-D-glucoside, and kaempferol-3-O(2″-O-galloyl)-β-D-glucoside. These and nine related compounds, (-)-quinic acid, (-)-shikimic acid, ellagic acid, kaempferol, quercetin, quercitrin, rutin, quercetin-3-O-(2″-O-galloyl)-β-D-rutinoside and 1,3,4,6-tetra-O-galloyl-β-D-glucose, were evaluated for the inhibitory activity against chitin synthase II and III. They inhibited chitin synthase II with IC50 values of 18-206 μM, except for two organic acids, (-)-quinic acid and (-)-shikimic acid. Among them, 3-O-galloyl-(-)-shikimic acid was the most potent inhibitor against chitin synthase II of Saccharomyces cerevisiae with an IC50 value of 18 μM. The inhibition appears to be selective for chitin synthase II, as they did not appreciably inhibit chitin synthase III.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2001-16487

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)