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Title 

Hepatitis B virus X 형질전환 생쥐와 인체 간세포암종에서 proliferating cell nuclear antigen 발현과 자멸사

Authors 

Hyung Bae MoonDae Yeul YuHyung Ryun YooByung Joon SoKwon Mook ChaeHak Cheol KimKi Jung YunWon Cheol HanHyang Jeong JoBo Yong Kim

Issue Date 

2001

Citation 

Korean Journal of Pathology, vol. 35, no. 2, pp. 129-136

Keywords 

transgenichepatocellularcarcinomaproliferating cell nuclear antigenapoptosis

Abstract 

Background : This experiment was designed to study the cell kinetics of hepatocellular carcinoma (HCC) in both hepatitis B virus X (HBx) transgenic mice and humans. Methods : The immunohistochemical stain of proliferating cell nuclear antigen (PCNA) and TdT-mediated dUTP-biotin nick end labeling (TUNEL) assay of apoptosis were used on formalin fixed-paraffin embedded tissues. Results : PCNA labeling indices (PCNA-LI) in the liver of HBx transgenic mice were markedly increased in HCC (11.3%) compare to the dysplastic areas (1.3%) and in the liver of non-transgenic littermates (0.1%). There was no significant difference of PCNA-LI in the dysplastic areas between HCC developed mice and non-HCC developed mice. Apoptosis labeling indices (Apoptosis-LI) in both the dysplastic areas and HCC of HBx transgenic mice were similar to those of non-transgenic littermates. PCNA-LI was markedly increased in human HCC (28.9%) compare to the background of HCC (2.9%) and the control liver (2.9%). Apoptosis-LI was decreased in human HCC (0.3%) compare to the background of HCC (0.4%) and the control liver (1.0%). Conclusion : There is a marked increase of cell proliferating activity in human HCC and in HCC of HBx transgenic mice, and there is a decrease of apoptosis in human HCC, but not in HCC of HBx transgenic mice.

ISSN 

0379-1149

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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